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Exploring the Shared Genetic Architectures between Primary Open-Angle Glaucoma and Visual Pathway Regions in the Brain
2025-06-06
ophthalmology
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PurposeTo investigate the genetic relationships between primary open-angle glaucoma (POAG) and major visual pathways in the brain to better understand the neurological biology of glaucoma, which may facilitate the discovery of neuroprotective drug targets. MethodsWe assessed the relationship between POAG and the volumes of five visual pathway regions using genetic correlation and polygenic risk score (PRS). We further used Mendelian randomisation (MR) to investigate the causal relationships. In...
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