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Normative Brain Entropy Across the Lifespan

Del Mauro, G.; Zeng, X.; Wang, Z.

2025-05-14 neuroscience
10.1101/2025.05.08.652915 bioRxiv
Show abstract

Brain entropy (BEN), a measure of the complexity and irregularity of neural has emerged as a promising marker for cognitive and clinical traits. However, normative lifespan trajectories of BEN remain underexplored. In this study, we investigated age-related changes in BEN across the human lifespan using Sample Entropy (SampEn). BEN was estimated from resting-state fMRI data collected from multiple Human Connectome Project cohorts (N = 2,415, ages 8-89 years), and normative growth curves were modeled using the GAMLSS framework. Results revealed a nonlinear increase in average BEN from childhood to older adulthood, with females exhibiting significantly higher BEN than males. Regional and network-level analyses confirmed similar age-related patterns.

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