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Cross-scale prediction of glioblastoma MGMT methylation status based on deep learning combined with magnetic resonance images and pathology images
2025-05-08
radiology and imaging
Title + abstract only
View on medRxiv
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BackgroundIn glioblastoma (GBM), promoter methylation of the O6-methylguanine-DNA methyltransferase (MGMT) is associated with beneficial chemotherapy but has not been accurately evaluated based on radiological and pathological sections. To develop and validate an MRI and pathology image-based deep learning radiopathomics model for predicting MGMT promoter methylation in patients with GBM. MethodsA retrospective collection of pathologically confirmed isocitrate dehydrogenase (IDH) wild-type GBM ...
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