EBV-positive Hodgkin lymphoma with immunosuppressive microenvironment during IL-23 inhibitor therapy for psoriasis
Shah, B.; Franco-Barraza, J.; Cai, K.; Dmitrieva, M.; Messmer, M.; Yang, Y.; Wasik, M.; Cukierman, E.; Nejati, R.
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We report the initial case of EBV-positive classic Hodgkin lymphoma (cHL) after guselkumab therapy for psoriasis. High-plex spatial proteomic analysis showed a Th2-polarized immunosuppressive tumor microenvironment, indicating immune reprogramming from IL-23 inhibition might have triggered the onset of EBV-positive cHL.
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