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Oxytocin and its role in energy balance and metabolic factors: A living systematic review and meta-analysis protocol

Sartorius, A. I.; Kang, H.; Deilhaug, E.; Walle, K. M.; Lawson, E. A.; Eddy, K.; van der Meer, D.; Tjelta Westlye, L.; Quintana, D. S.

2025-04-04 endocrinology
10.1101/2025.04.04.25325238 medRxiv
Show abstract

Oxytocin is a neuropeptide that first received research attention for its role in parturition and lactation and has since been implicated in various cognitive and behavioral processes. More recently, evidence has shown that oxytocin is also involved in additional physiological domains, such as energy balance and metabolism. To our knowledge, no recent meta-analysis on the effects of exogenous oxytocin on energy balance and metabolism has been conducted. With this article, we present a protocol that describes the plan for a living systematic review and meta-analysis investigating the role of oxytocin in energy regulation and metabolism, as well as the variables which may moderate this potential effect.

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