Humoral Immunity Against Orthopoxvirus in Vaccinated and Unvaccinated Individuals during 2022 Mpox Outbreak
Li, Y.; Townsend, M. B.; Li, S.; Testa, Q. E.; Medvec, T.; Thompson, E. A.; Palella, F. J.; Mimiaga, M. J.; Brock, J. B.; Alcaide, M. L.; Sheth, A. N.; Floris-Moore, M.; Chandran, A.; French, A. L.; Tien, P. C.; Merenstein, D. J.; Augenbraun, M.; Sharma, A.; Moran, C. A.; Rinaldo, C. R.; Macatangay, B. J.; Satheshkumar, P. S.; Ho, K. S.
Show abstract
Little is known about serological responses to MVA-BN (JYNNEOS) against mpox in elderly individuals with or without HIV. In this study, MVA-BN induced sustained IgG levels regardless of HIV status even up to one year. Birth before 1973 correlated with higher IgG. MVA-BN unvaccinated individuals with HIV had lower IgG than vaccinated.
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