NEMF inhibits proliferation and migration of ovarian cancer cells by blocking the PI3K/mTOR pathway
Wang, Q.; Zhu, Y.; Zhang, Y. l.; Chen, C. z.; Jing, F.; Yin, A. q.; Guo, S. q.; Liu, Y. h.
Show abstract
Nuclear export mediator factor (NEMF) is considered to be a tumor suppressor in Drosophila. Based on the analysis of data from an online database, NEMF is downregulated in ovarian cancer. However, the mechanism underlying its expression has not been reported thus far.In this study, the immunohistochemistry results showed that the expression of NEMF may be related to patient age and tissue differentiation. In vitro experiments indicated that overexpression of NEMF may inhibit cell proliferation and migration by inhibiting the PI3K/mTOR signaling pathway, thereby blocking cell cycle progression and promoting apoptosis (P < 0.05).Therefore, we speculate that NEMF is a potential tumor suppressor gene. Targeting NEMF may be an innovative therapeutic approach for ovarian cancer. Summary blurbNEMF is downregulated in ovarian cancer and the mechanism underlying its expression has not been reported thus far.In vitro experiments indicated that overexpression of NEMF inhibit cell proliferation and migration by inhibiting the PI3K/mTOR signaling pathway,thereby blocking cell cycle progression.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer 94%
- Fibroblast activation during decidualization: Embryo-derived TNFα induction of PGI2-PPARδ-ACTIVIN A pathway through luminal epithelium 94%
- ACVR2A Facilitates Trophoblast Cell Invasion through TCF7/c-JUN Pathway in Pre-eclampsia Progression 94%
Similar papers in this journal
- Cyclin G2 inhibits oral squamous cell carcinoma growth and metastasis by binding to insulin-like growth factor binding protein 3 and regulating the FAK-SRC-STAT signaling pathway 96%
- miR-100-5p downregulates mTOR to suppress the proliferation, migration and invasion of prostate cancer cells 95%
- Patient stratification of clear cell renal cell carcinoma using the global transcription factor activity landscape derived from RNA-seq data 94%
Similar papers in this journal
- Serum hormone levels in infertile women between conceived with and without hormone replacement therapy: Safety of estradiol and progesterone replacement therapy in frozen-thawed embryo transfer cycles for breast cancer survivors. 94%
- Classification of clear cell renal cell carcinoma based on PKM alternative splicing 94%
- A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.