Study on the Intervention of α-Lipoic Acid in Patients with Type 2 Diabetes Mellitus after CAG or PCI Compared with Contrast-Induced Nephropathy

ObjectiveTo investigate the effect of -lipoic acid on contrast-induced nephropathy (CIN) in diabetic patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). MethodsPatients diagnosed with type 2 diabetes mellitus and coronary heart disease scheduled for CAG or PCI treatment at the Department of Cardiovascular Medicine, General Hospital of Ningxia Medical University from February 1, 2021, to August 30, 2023, were recruited. After obtaining informed consent, patients were allocated into three groups: -lipoic acid group (38 cases), adequate hydration group (60 cases), and routine hydration group (104 cases).The primary outcome observed was the incidence of CIN, and secondary endpoints included changes in SCr, TBiL, and GGT 72 hours after contrast agent administration. ResultsThe incidence of CIN in the -lipoic acid group was 2.63% (1/38), 1.67% (1/60) in the adequate hydration group, and 4.81% (5/104) in the routine hydration group, with no statistically significant difference among the three groups (p=0.544). After PCI or CAG, SCr levels decreased slightly more in the -lipoic acid group compared to the adequate hydration group, while the routine hydration group showed an increase, but the differences were not statistically significant (p> 0.05). Conclusion-Lipoic acid has a certain improvement effect on renal function indicators (Scr) after CAG or PCI, but it did not demonstrate a significant preventive effect on CIN. Adequate hydration showed greater reduction in oxidative stress damage after CAG or PCI compared to -lipoic acid and routine hydration.