Bitter taste genetics and oral health in Canadian Longitudinal Study on Aging
Shafizadeh, M.; Bhatia, V.; Ahmed, S.; Drogemoller, B.; Stavropoulou, C.; St. John, P.; Bhullar, R.; Chelikani, P.; Hitchon, C.
Show abstract
This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) in 25 Bitter Taste Receptor genes (TAS2Rs) and 12 TAS2R pseudogenes with self-reported oral health outcomes in the Canadian Longitudinal Study on Aging (CLSA) cohort. Following quality control, 124 SNPs with a minor allele frequency > 0.01 and 21,991 individuals of European ancestry were included in the analysis. Fifteen SNPs in TAS2R8, 9, 13, 14, 20, and 50 were significantly associated with self-reported sore jaw muscles, a symptom commonly linked to temporomandibular disorders (TMDs). TAS2R20 exhibited the highest number of associated SNPs. Structure-function analysis suggests that variants in TAS2R20 may contribute to this symptom by altering ligand interactions. These findings highlight the potential for TAS2R genetic screening to identify individuals at elevated risk for TMD, supporting the development of personalized treatment strategies and advancing our understanding of TMD genetic risk factors.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Multiple nutritional and gut microbial factors associated with allergic rhinitis: the Hitachi Health Study 92%
- Co-localized SNPs Affecting the Expression of Taste Perception Genes are linked to Alzheimer's Disease 91%
- Association of Streptococcus mutans harboring bona-fide collagen binding proteins and Candida albicans with early childhood caries recurrence 91%
Similar papers in this journal
Similar papers in this journal
- Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health 91%
- Social isolation is linked to classical risk factors of Alzheimer's disease-related dementias 91%
- Risk of complications among diabetics self-reporting oral health status in Canada: A population-based cohort study 91%
Similar papers in this journal
- Homozygote loss-of-function variants in the human COCH gene underlie hearing loss 89%
- A genome-wide association analysis of loss of ambulation in dystrophinopathy patients suggests multiple candidate modifiers of disease severity 89%
- Exploiting Family History in Aggregation Unit-based Genetic Association Tests 88%
Similar papers in this journal
- Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy and periventricular calcifications 89%
- Missense variants affecting the actin-binding domains of PLS3 cause X-linked congenital diaphragmatic hernia and body wall defects 89%
- Loss-of-function of the Zinc Finger Homeobox 4 ( ZFHX4 ) gene underlies a neurodevelopmental disorder 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.