Reversible Transcriptomic Age Shifts from Physiological Stress in Whole Blood
Bhak, J.; Nam, D.; An, K.; Kwon, Y.; Bhak, J.; Jeon, S.; Ryu, H.
Show abstract
We developed a genome-wide transcriptomic clock for predicting chronological age using whole blood samples from 463 healthy individuals. Our findings reveal profound age acceleration, up to 24.47 years, under perturbed homeostasis in COVID-19 patients, which reverted to baseline upon recovery. This study demonstrates that the whole blood transcriptome can track reversible changes in biological age induced by stressors in real physiological time, suggesting a potential role for anti-aging interventions in disease management.
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