Back

Imputed DNA methylation outperforms measured loci associations with smoking and chronological age

Richmond, A.; Mur, J.; Harris, S.; Corley, J.; Elliott, H. R.; Foley, C. N.; Hannon, E.; Kuncheva, Z.; Min, J.; Moqri, M.; Ndiaye, M.; Sun, B.; Vallejos, C.; Ying, K.; Gladyshev, V. N.; Cox, S. R.; McCartney, D. L.; Marioni, R.

2024-09-10 genetics
10.1101/2024.09.05.611501 bioRxiv
Show abstract

Multi-locus signatures of blood-based DNA methylation are well-established biomarkers for lifestyle and health outcomes. Here, we focus on two CpGs that are strongly associated with age and smoking behaviour. Imputing these loci via epigenome-wide CpGs results in stronger associations with outcomes in external datasets compared to directly measured CpGs. If extended epigenome-wide, CpG imputation could augment historic arrays and recently-released, inexpensive but lower-content arrays, thereby yielding better-powered association studies.

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

1
Clinical Epigenetics
○ 53 papers in training set
Top 0.1%
33.7%
2
Human Molecular Genetics
◐ 130 papers in training set
Top 0.1%
12.8%
3
Nature Communications
○ 4913 papers in training set
Top 17%
10.3%
50% of probability mass above
4
GeroScience
○ 97 papers in training set
Top 0.2%
7.3%
5
Epigenetics
○ 43 papers in training set
Top 0.1%
6.5%
6
Genome Medicine
○ 154 papers in training set
Top 1%
4.4%
7
Nature Aging
○ 51 papers in training set
Top 0.4%
4.1%
8
Aging Cell
○ 144 papers in training set
Top 2%
2.1%
9
Scientific Reports
○ 3102 papers in training set
Top 61%
1.5%
10
eLife
● 5422 papers in training set
Top 45%
1.5%
11
Frontiers in Genetics
○ 197 papers in training set
Top 7%
1.0%
12
eBioMedicine
○ 130 papers in training set
Top 3%
1.0%
13
Cell Genomics
○ 162 papers in training set
Top 5%
1.0%
14
Cell Reports
○ 1338 papers in training set
Top 32%
0.8%
15
Genome Biology
○ 555 papers in training set
Top 7%
0.8%
16
Aging
○ 69 papers in training set
Top 3%
0.8%
17
PLOS ONE
● 4510 papers in training set
Top 71%
0.7%
18
Science Advances
● 1098 papers in training set
Top 32%
0.7%
19
European Journal of Human Genetics
○ 49 papers in training set
Top 2%
0.7%
20
The American Journal of Human Genetics
○ 206 papers in training set
Top 5%
0.5%
21
Nucleic Acids Research
◐ 1128 papers in training set
Top 21%
0.5%
22
Nature Human Behaviour
○ 85 papers in training set
Top 5%
0.5%