Decrypting the phylogenetics history of EGF-CFC proteins Cripto and Cryptic.
Shylo, N.; Trainor, P.
Show abstract
EGF-CFC proteins are obligate coreceptors for Nodal signaling and are thus required for gastrulation and left-right patterning. Species with multiple family members show evidence of specialization. For example, mouse Cripto is required for gastrulation, whereas Cryptic is involved in left-right patterning. However, the members of the family across model organisms have little sequence conservation beyond the EGF-CFC domain, posing challenges for determining their evolutionary history and functional conservation. In this study we outline the evolutionary history of the EGF-CFC family of proteins. We traced the EGF-CFC gene family from a single gene in the deuterostome ancestor through its expansion and functional specialization in tetrapods, and subsequent gene loss and translocation in eutherian mammals. Mouse Cripto and Cryptic, zebrafish Tdgf1, and all three Xenopus EGF-CFC genes (Tdgf1, Tdgf1.2 and Cripto.3) and are all descendants of the ancestral Tdgf1 gene. We propose that subsequent to the family expansion in tetrapods, Tdgf1B (Xenopus Tdgf1.2) acquired specialization in the left-right patterning cascade, and after its translocation in eutherians to a different chromosomal location, Cfc1/Cryptic has maintained that specialization.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Cell culture-based shark karyotyping as a resource for chromosome-scale genome analysis 93%
- Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain 92%
- Targeted Transcriptome Analysis using Synthetic Long Read Sequencing Uncovers Isoform Reprograming in the Progression of Colon Cancer 92%
Similar papers in this journal
- Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus 94%
- The whale shark genome reveals patterns of vertebrate gene family evolution 93%
- In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins 93%
Similar papers in this journal
- Evolution and expression of Glial Cells Missing (GCM1 and GCM2) in monotremes suggests an ancient role in reproduction and placentation 95%
- GNL3 is an evolutionarily-conserved stem cell gene influencing cell proliferation, animal growth, and regeneration in the hydrozoan Hydractinia 92%
- Terminal regions of a protein are a hotspot for low complexity regions (LCRs) and selection 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.