Cell cycle re-entry in the aging Drosophila brain.
Damschroder, D.; Sun, J.; McDonald, K. O.; Buttitta, L.
Show abstract
The brain is an organ comprised mostly of long-lived, quiescent cells that perform vital functions throughout an animals life. Due to the brains limited regenerative ability, these long-lived cells must engage unique mechanisms to cope with accumulated damage over time. We have shown that a subset of differentiated neuronal and glial cells in the fruit fly brain become polyploid during adulthood. Cell cycle re-entry in the brain has previously been associated with neurodegeneration, but there may be a more complex relationship between polyploidy and cell fitness in the brain. Here, we examine how known lifespan modifiers influence the accumulation of polyploidy in the aging fly brain. Flies aged at a low temperature, or with a low protein diet, accumulate polyploid cells in the brain more slowly than expected if this phenotype were solely regulated by lifespan mechanisms. Despite the slower accumulation of polyploid cells, animals under conditions that extend lifespan eventually reach similar levels of polyploidy in the brain as controls. Our work suggests known lifespan modifiers can influence the timing of cell cycle re-entry in the adult brain, indicating there is a flexible window of cell cycle plasticity in the aging brain.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Loss of vacuolar acidity results in iron sulfur cluster defects and divergent homeostatic responses during aging in Saccharomyces cerevisiae 96%
- Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1 independent transcriptional response. 96%
- Knockdown of the fly spliceosome component Rbp1(orthologue of SRSF1) extends lifespan 94%
Similar papers in this journal
- Oocyte Aging is Controlled by Mitogen Activated Protein Kinase Signaling 95%
- V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is aPhenotypic Driver of Lysosome Dysfunction in Replicative Aging 95%
- Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging 95%
Similar papers in this journal
- Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila 96%
- Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes 95%
- Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. 95%
Similar papers in this journal
Similar papers in this journal
- Axin-mediated regulation of lifespan and muscle health in C. elegans involves AMPK-FOXO signaling 96%
- A role for cell polarity in lifespan and mitochondrial quality control in the budding yeast Saccharomyces cerevisiae 96%
- Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.