Interaction between mitochondrial translocator protein and aging in inflammatory responses in mouse hippocampus
Lai, K. O.; Tham, N.; Fairley, L.; Naik, R. R.; Langley, S. R.; Barron, A. M.
Show abstract
The mitochondrial translocator protein (TSPO) is a biomarker of inflammation which is upregulated in the brain in aging and associated neurodegenerative diseases, such as Alzheimers disease (AD). Here we investigated the interaction between aging and TSPO immunomodulatory function in mouse hippocampus, a region severely affected in AD. Aging resulted in a reversal of TSPO knockout transcriptional signatures following inflammatory insult, with TSPO deletion drastically exacerbating inflammatory transcriptional responses in the aging hippocampus whilst dampening inflammation in the young hippocampus. Drugs that disrupt cell cycle and induce DNA-damage such as heat shock protein and topoisomerase inhibitors were identified to mimic the inflammatory transcriptional signature characterizing TSPO-dependent aging most closely. This TSPO-aging interaction is an important consideration in the interpretation of TSPO-targeted biomarker and therapeutic studies, as well as in vitro studies which cannot model the aging brain.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Functional genomic analyses highlights a shift in Gpr17-regulated cellular processes in oligodendrocyte progenitor cells (OPC) and underlying myelin dysregulation in the aged forebrain 98%
- Age-associated transcriptomic and epigenetic alterations in mouse hippocampus 98%
- S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice 96%
Similar papers in this journal
- A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging 95%
- Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging 95%
- Aging is associated with increased brain iron through brain-derived hepcidin expression 95%
Similar papers in this journal
- Age-Dependent Maturation and Rejuvenation of the Neural 3D Chromatin Interactome in Enriched Environments 96%
- Defining the age-dependent and tissue-specific circadian transcriptome in male mice 96%
- Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging 95%
Similar papers in this journal
- Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice 94%
- Engram reactivation during memory retrieval predicts long-term memory performance in aged mice 94%
- Reduced Cognitive Performance in Aged Rats Correlates with Increased Excitation/Inhibition Ratio in the Dentate Gyrus in Response to Lateral Entorhinal Input 94%
Similar papers in this journal
- Shifted dynamics of glucose metabolism in the hippocampus during aging 95%
- Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus 95%
- A meta-analysis of brain DNA methylation across sex, age and Alzheimer’s disease points for accelerated epigenetic aging in neurodegeneration 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.