Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy
Valentino, T. R.; Burke, B. I.; Kang, G.; Goh, J.; Dungan, C. M.; Ismaeel, A.; Mobley, C. B.; Flythe, M. D.; Wen, Y.; McCarthy, J. J.
Show abstract
Regular exercise yields a multitude of systemic benefits, many of which may be mediated through the gut microbiome. Here, we report that cecal microbial transplants (CMTs) from exercise-trained vs. sedentary mice have modest benefits in reducing skeletal muscle atrophy using a mouse model of unilaterally hindlimb-immobilization. Direct administration of top microbial-derived exerkines from an exercise-trained gut microbiome preserved muscle function and prevented skeletal muscle atrophy.
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