Hepatitis E virus infection upregulates ING5 expression in vitro and vivo
Zhao, W.; Xia, Y.; Li, T.; Liu, H.; Zhong, G.; Chen, D.; Yu, W.; Li, Y.; Huang, F.
Show abstract
Hepatitis E virus (HEV) is the major pathogen of viral hepatitis. Immunocompromised individual infected by HEV is prone to chronic hepatitis and increases the risk of hepato-cellular carcinoma (HCC). Inhibitor of growth family member 5 (ING5) is a tumor suppressor gene, is low expressed in cancer tumor or cells. However, the underlying relationship between ING5 and HEV infection is unclear. In the present study acute and chronic HEV animal models were employed to explore the interaction between ING5 and HEV. Notably, the expression of ING5 was significantly increased both in the liver of acute HEV infected BALB/c mice and chronic HEV infected rhesus macaques. In addition, the relationship between HEV infection and ING5 expression was further identified in human hepatoma (HepG-2) cells. In conclusion, HEV infection strongly upregulated ING5 expression in vivo and in vitro, bearing significant implications in further understanding the pathogenic mechanism of HEV infection.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mosquito defensins enhance Japanese encephalitis virus infection by facilitating virus adsorption and entry within mosquito 95%
- Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation 95%
- DNA damage response signaling is crucial for effective Chikungunya virus replication 95%
Similar papers in this journal
- PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response 95%
- Difference in TMPRSS2 usage by Delta and Omicron variants of SARS-CoV-2: Implication for a sudden increase among children 95%
- Epidemiological survey of serum titers from adults against various Gram-negative bacterial V-antigens 94%
Similar papers in this journal
- Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS-CoV-2 variants 95%
- SARS-CoV-2 ORF9b Antagonizes Type I and III Interferons by Targeting Multiple Components of RIG-I/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING Signaling Pathways 94%
- Identification of novel wraparound transcripts in JC polyomavirus 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.