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Diabetes Advances Cardiomyocyte Senescence through miR-103a-3p/ Rnd3/STAT3 Signaling

2024-01-17 cardiovascular medicine Title + abstract only
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BACKGROUNDRnd3, a small Rho-GTPase, is involved in various cardiovascular diseases, but its role in diabetes-induced cardiomyocyte senescence is unclear. This study aims to investigate the role of Rnd3 in cardiomyocyte senescence in diabetes cardiomyopathy (DCM). METHODSRnd3 expression was assessed in human tissue using qPCR, and its correlation with clinical parameters was analyzed. Rnd3 and Senescence-associated secretory phenotype (SASP)-related marker expression was determined in heart tiss...

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