Association of Metabolic Dysfunction-Associated Steatotic Pancreas Disease (MASPD) with Insulin Resistance

Introduction"Metabolic Dysfunction-Associated Steatotic Pancreas Disease" (MASPD) is not yet a term or condition described in the medical literature. The MASPD is a relatively new and emerging condition that has garnered significant attention in the field of metabolic disorders. Objectiveto investigate the association between MASPD and IR and explore the potential mechanisms that may contribute to this relationship. Materials and MethodsThis cross-sectional study involved 157 participants diagnosed with MASPD based on ultrasonography criteria. Baseline demographic data were collected, including age, gender, and body mass index. Serum levels of fasting glucose, insulin, lipid profile (including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol), glycated hemoglobin and insulin were measured using standardized laboratory techniques. Abdominal ultrasonography was performed on all participants using convex transducer (frequency range, 3,5 MHz) by experienced radiologist blinded to the clinical data. The association between MASPD and IR was assessed using logistic regression analysis, adjusting for potential confounders. Statistical significance was set at a p-value of less than 0.05. ResultsThe logistic regression analysis was performed to verify whether IR was a risk factor for MASPD. After adjusting for gender and age, the results demonstrate a significant correlation between MDASPD and markers of IR. TyG index: OR (95% IC) 5.72 (1.90 - 16.00), P 0.021, and HOMA -IR: OR (95% IC) 6.20 (2.1 - 22.00) P 0.037. ConclusionThis study presents the first description of MDASPD and its association with IR indices. Our findings demonstrate a significant correlation between MDASPD and markers of IR. These results suggest that MDASPD may contribute to the development of insulin resistance and further highlight the importance of pancreatic health in metabolic disorders.