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Inferring vaccine efficacy and mode of action from human challenge studies
2023-09-25
infectious diseases
Title + abstract only
View on medRxiv
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To assess the long-term effect of a vaccination programme, understanding both the efficacy and the mode of action of the vaccine is crucial. The actual mode of action is difficult to infer from field trials, because of the heterogeneity of exposure to infection. Here we show an approach to determine both vaccine efficacy and the mode of action of vaccines from human challenge studies. Our approach reveals how vaccines alter an individuals susceptibility, and identifies a mixture of different mod...
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