Tuning gene expression to music: the compensatory effect of music on age-related cognitive disorders
Gomez-Carballa, A.; Navarro, L.; Pardo-Seco, J.; Bello, X.; Pischedda, S.; Viz-Lasheras, S.; Camino-Mera, A.; Curras, M. J.; Ferreiros, I.; Mallah, N.; Rey-Vazquez, S.; Redondo, L.; Dacosta-Urbieta, A.; Caamanho-Vinha, F.; Rivero-Calle, I.; Rodriguez-Tenrreiro, C.; Martinon-Torres, F.; Salas, A.
Show abstract
Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n=60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimers disease (AD) as revealed by a multi-cohort study (n=1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders.
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