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Adult Mouse Leptomeninges Exhibit Regional and Age-related Cellular Heterogeneity and Gene Expression Differences Implicating Mental Disorders

Allen, C. A.; Goderie, S. A.; Liu, M.; Kiehl, T. R.; Farjood, F.; Wang, Y.; Boles, N. C.; Temple, S.

2023-09-13 neuroscience
10.1101/2023.09.10.557097 bioRxiv
Show abstract

The leptomeninges envelop the central nervous system (CNS) and contribute to cerebrospinal fluid (CSF) production and homeostasis. We analyzed the meninges overlying the anterior or posterior forebrain in the adult mouse by single nuclear RNA-sequencing (snucRNA-seq). This revealed regional differences in fibroblast and endothelial cell composition and gene expression. Surprisingly, these non-neuronal cells co-expressed genes implicated in neural functions. The regional differences changed with aging, from 3 to 18 months. Cytokine analysis revealed specific soluble factor production from anterior vs posterior meninges that also altered with age. Secreted factors from the leptomeninges from different regions and ages differentially impacted the survival of anterior or posterior cortical neuronal subsets, neuron morphology, and glia proliferation. These findings suggest that meningeal dysfunction in different brain regions could contribute to specific neural pathologies. The disease-associations of meningeal cell genes differentially expressed with region and age were significantly enriched for mental and substance abuse disorders.

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