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Identification of Spinster Homolog 3 as a novel putative LL-37 receptor

Correa, A. B.; de Lima, T. M.; Ariga, S. K.; Pinheiro Da Silva, F.

2023-07-10 immunology
10.1101/2023.07.07.548096 bioRxiv
Show abstract

BackgroundAntimicrobial Peptides are primitive components of the innate immune response. LL-37, a human antimicrobial peptide, has been researched for its therapeutic potential in immune-inflammatory diseases. This study aimed to identify novel LL-37 receptors. Methods and ResultsUsing the phage display technique, the sequence GNWSFV was selected and found to bind to LL-37. BLAST analysis revealed that this sequence has a high degree of similarity to a portion of human transmembrane protein Spinster Homolog 3. ConclusionOur study suggests that Spinster Homolog 3 may be a potential therapeutic target for LL-37-related diseases.

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