Social Capital Associates with Cognitive Health, Oral Health and Epigenetic Age Deceleration: A Cross-sectional Analysis of the Canadian Longitudinal Study on Aging (CLSA)
Liang, A.; Gomaa, N.
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ObjectivesTo quantify the association of social capital, defined as social relationships and networks, with cognitive health, oral inflammation, and epigenetic aging. MethodsWe used data from the Canadian Longitudinal Study on Aging (CLSA) (n=1,479; ages 45-85 years), categorizing social capital as structural and cognitive capital. Oral inflammation was determined as the presence of gum bleeding. Epigenetic aging was computed as the difference between chronological age and DNA methylation age. Multivariable regression models adjusted for covariates were used. ResultsHigher structural social capital was associated with decelerated epigenetic aging and better cognitive health outcomes. Higher cognitive social capital was also associated with better cognitive outcomes and less oral inflammation. ConclusionEnhancing social capital may contribute to better clinical and biological outcomes around aging. Visual Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=117 SRC="FIGDIR/small/23292314v1_ufig1.gif" ALT="Figure 1"> View larger version (26K): org.highwire.dtl.DTLVardef@ed255dorg.highwire.dtl.DTLVardef@1302526org.highwire.dtl.DTLVardef@1d6fc0borg.highwire.dtl.DTLVardef@13d457b_HPS_FORMAT_FIGEXP M_FIG C_FIG
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