Back

Performance of cellular senescence measure, p16, and DNA methylation clocks in a clinically relevant model of age acceleration

2023-05-14 oncology Title + abstract only
View on medRxiv
Show abstract

Cellular senescence and DNA methylation are primary aging mechanisms emerging as a potential means of monitoring human aging and evaluating interventions thought to either accelerate or slow an individuals aging trajectory. However, it is largely unknown whether cellular senescence and signatures of methylation of the specific CpG islands that comprise various epigenetic clocks correlate in humans. We have measured the cellular senescence biomarker, p16 and the five most used epigenetic aging cl...

Predicted journal destinations

1
Cancers
57 training papers
Top 3% 9.0%
2
Nature Communications
483 training papers
Top 13% 7.8%
3
Clinical Epigenetics
21 training papers
#1 6.4%
4
Aging Cell
21 training papers
Top 0.2% 6.4%
5
Scientific Reports
701 training papers
Top 38% 6.4%
6
eLife
262 training papers
Top 3% 6.4%
7
PLOS ONE
1737 training papers
Top 77% 5.9%
8
Proceedings of the National Academy of Sciences
100 training papers
Top 1% 5.6%
9
Frontiers in Oncology
34 training papers
Top 3% 5.0%
10
Clinical Cancer Research
22 training papers
Top 2% 5.0%
11
Aging
18 training papers
#1 4.2%
12
Cancer Medicine
17 training papers
Top 3% 1.9%
13
iScience
74 training papers
Top 3% 1.9%
14
Cell Reports
25 training papers
Top 0.2% 1.9%
15
British Journal of Cancer
22 training papers
Top 3% 1.9%
16
Frontiers in Immunology
140 training papers
Top 8% 1.5%
17
BMC Cancer
21 training papers
Top 4% 1.3%
18
JAMA Network Open
125 training papers
Top 20% 1.2%
19
International Journal of Molecular Sciences
39 training papers
Top 4% 1.1%
20
Communications Biology
36 training papers
Top 3% 1.0%
21
Journal of Clinical Investigation
50 training papers
Top 4% 0.9%
22
Cell Reports Medicine
49 training papers
Top 5% 0.9%
23
Nature Genetics
72 training papers
Top 10% 0.7%
24
Nature
58 training papers
Top 10% 0.7%
25
Nature Medicine
88 training papers
Top 18% 0.7%
26
The American Journal of Clinical Nutrition
16 training papers
Top 2% 0.7%