Alopecosa nagpag acts on cardiac ventricular myocytes to kill prey
huang, b.
Show abstract
Spiders are excellent predator to kill their prey by peptide toxins from its venoms. Alopecosa nagpag (A. nagpag) is a new identified wolf spider distributing in Yunnan province and nothing has known about the venom. In this study, venom of A. nagpag showed mild toxicity to Kunming mouse with LD50 of 3.32 mg/kg. Action potential duration (APD) was prolonged in a frequency-dependent manner and whole currents of neonatal rat ventricular myocytes (NRVMs) were inhibited by venom. Meanwhile, venom of A. nagpag could largely increase L calcium currents (ICaL). Whereas sodium current (INa) and rapidly activating delayed rectifier potassium current (IKr) were significantly decreased by 100 g/mL venoms. No obvious inhibition was found on other ion channels such as rapidly activating and inactivating transient inward (IK1), rapid (IKr) and slow (IKs). As those ion channels play critical role in rhythm of cardiac ventricular myocytes, A. nagpag may lead prey to death by changing cardiac rhythm.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Consecutive treatments of methamphetamine promote the 4 development of cardiac pathological symptoms in zebrafish 95%
- In silico analysis and in planta production of recombinant ccl21/IL1β protein and characterization of its in vitro anti-tumor and immunogenic activity 93%
- Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors 93%
Similar papers in this journal
- Identification and characterization of novel proteins from Arizona bark scorpion venom that inhibit Nav1.8, a voltage-gated sodium channel regulator of pain signaling 94%
- A wolf in another wolf's clothing. Post-genomic regulation dictates venom profiles of medically-important cryptic kraits in India 93%
- Toxicokinetics of citreoviridin in vivo and in vitro. 91%
Similar papers in this journal
Similar papers in this journal
- Transmural and rate-dependent profiling of drug-induced arrhythmogenic risks through in silico simulations of multichannel pharmacology 94%
- Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter 93%
- Enhanced expression of Dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including Diaphragm of mdx mice after oral administration of Neu REFIX Beta 1,3-1,6 glucan 93%
Similar papers in this journal
- The mitochondrial deubiquitinase USP30 regulates AKT/mTOR signaling 93%
- Protein kinases mediate anti-inflammatory effects of cannabidiol and estradiol against high glucose in cardiac sodium channels 93%
- Evaluation of modulators of cAMP-response in terms of their impact on cell cycle and mitochondrial activity of Leishmania donovani 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.