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Cohort Profile: Zhejiang Environmental and Birth Health Research Alliance (ZEBRA) Maternity Cohort

Sun, H. Z.; Tang, H.; Xiang, Q.; Xu, S.; Fang, J.; Dai, H.; Shi, R.; Pan, Y.; Luo, T.; Jin, H.; Ji, C.; Chen, Y.; Liu, H.; Zhao, M.; Tang, K.; Guo, Y.; Xu, W.; Bai, X.; Zhejiang Environmental and Birth Health Research Alliance (ZEBRA) collaborative group,

2023-02-24 epidemiology
10.1101/2023.02.21.23286173 medRxiv
Show abstract

The Zhejiang Environmental and Birth Health Research Alliance (ZEBRA) established a maternity cohort to investigate the relationship between perinatal abnormalities and various risk factors among the Chinese maternal population. The primary aim of ZEBRA is to explore the feasibility of early-stage risk prediction and the forecast of adverse perinatal symptoms and gestational outcomes. The cohort is ambidirectional, with a retrospective arm tracking 6,275 pregnant females enrolled between 2013 and 2016, and a prospective arm recruiting 112,414 participants since the baseline year of 2017. The current ZEBRA maternity cohort database comprises a diverse range of sociodemographic features, physiological characteristics, medical history, therapeutic interventions, and measurements of environmental exposures. Going forward, the cohort will continue to enrol a wider range of participants and collect an even more extensive array of features. ZEBRA is seeking collaborations with both national and international multi-cohort studies to contribute to the field of epidemiology, and provide valuable evidence-based insights for global maternal and child healthcare.

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