Targeting GDF15 as a potential therapy for low back pain originating from endplate
Li, X.; Wu, J.; Kong, Q.; Hu, M.; Wei, Z.; Jiang, H.; Zhang, Z.; Zhou, X.; ma, j.
Show abstract
The overactivation of osteoclasts in the endplate is one of the most important causes of low back pain (LBP) originating from endplate. Transforming growth factor-{beta} family has been demonstrated to play an important role during osteoclast differentiation. GDF15 was reported to participate in several pathological states. In this study, we reported that the lumbar spine instability (LSI) induced the overactivation of osteoclasts and CD31hiEmcnhi endothelial vessels in the bony endplate. In addition, the expression of GDF15 in human disc samples and mice models were also increased. GDF15 could promote the fusion of preosteoclasts via Rac1/Cdc42/PAK/Cofilin axis, and facilitate the angiogenesis via the secretion of PDGF-BB. Furthermore, we proved that the GDF15 inhibitor, CTL-002 could reduce the expression of GDF15 in the endplate and alleviate the overactivation of osteoclasts and CD31hiEmcnhi endothelial vessels induced by LSI in vivo. In conclusion, we demonstrated that GDF15 could regulates the fusion of preosteoclasts and targeting GDF15 in the endplate served as a novel anabolic therapy for low back pain treatment.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- GLI1 facilitates rheumatoid arthritis by collaborative regulation of DNA methyltransferases 96%
- Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice 96%
- Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling 95%
Similar papers in this journal
Similar papers in this journal
- Moderate Static Magnetic Fields Prevent Estrogen Deficiency-Induced Bone Loss: Evidence from Ovariectomized Mouse Model and Small Sample Size Randomized Controlled Clinical Trial 95%
- RORβ modulates a gene program that is protective against articular cartilage damage 94%
- Platelet HMGB1 in Platelet-Rich Plasma Promotes Tendon Wound Healing 93%
Similar papers in this journal
- Modulation of TRPV4 Protects against Degeneration Induced by Sustained Loading and Promotes Matrix Synthesis in the Intervertebral Disc 93%
- The role of TGFβ signaling in Gli1+ tendon and enthesis cells 92%
- Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus 92%
Similar papers in this journal
- CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1 94%
- lncRNA DLEU2 acts as a miR-181a sponge regulated SEPP1 (may as a biomarker for sarcopenia) to inhibit skeletal muscle differentiation and regeneration 93%
- A systematic dissection of human primary osteoblasts in vivo at single-cell resolution 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.