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Transcriptome-wide association study identified candidate genes associated with polycystic ovary syndrome

2023-02-10 genetic and genomic medicine Title + abstract only
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Polycystic ovary syndrome (PCOS) is one of the most common metabolism and endocrine disorder affecting women of reproductive age. However, the genetic mechanisms of PCOS remain largely elusive. A transcriptome-wide association study(TWAS) was conducted to identify the genes associated with PCOS using gene expression references of the whole blood and ovary. Then mRNA expression profiling analysis was performed to identify common genes with TWAS. Genes detected by TWAS were subjected to Gene Ontol...

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