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Impact of human CD8+ T cell senescence on 89Zr radiolabelling and PET imaging

2023-02-07 radiology and imaging Title + abstract only
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The ability of CD8+ T cells to protect against infection and malignant transformation diminishes with age. Novel means to assess cellular functional deficits in vivo are being made available such as total-body positron emission tomography (PET) and radiotracers with long half-lives. Here, we determined radiolabeled human CD8+ T cells isolated from young and old individuals with zirconium-89 (89Zr) and assessed their biological status in vitro and distribution in vivo. MethodsFresh and cryoprese...

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