COVID-19 Induces Senescence And Exhaustion Of T Cells In Patients With Mild/Moderate And Severe Disease During A Seven-Day Interval
Pedroso, R.; Ventura, L. H. A.; Torres, L.; Camatta, G. C.; Caixeta, F.; Nascimento, L.; Mota, C.; Mendes, A. C.; Ribeiro, F.; Guimaraes, H. C.; Barbuto, R. C.; Silveira-Nunes, G.; Teixeira-Carvalho, A.; Graca, L.; Faria, A. M. C.
Show abstract
Risk factors for the development of severe COVID-19 include several comorbidities, but age was the most striking one since elderly people were disproportionately affected by SARS-Cov-2. Major drivers that can explain this markedly unfavourable response in the elderly are inflammaging and immunosenescence. Recent reports have shown that the relationship between immunosenescence and COVID-19 can be bidirectional, since hospitalized patients with severe COVID-19 have an accumulation of senescent T cells suggesting that immunosenescence can be also exacerbated by SARS-CoV-2 infection. Therefore, the present work was designed to examine the emergence of immunosenescence in a longitudinal study in two distinct cohorts of COVID-19 patients, and to determine whether the senescence alterations were restricted to severe cases of the disease. Our data, with patients from Portugal and Brazil, identified their distinctive inflammatory profile and provided evidence of increased frequencies of senescent and exhausted T cells within a seven-day period in patients with mild to severe COVID-19. These results support the view that SARS-CoV2 infection can accelerate immunosenescence in both CD4 and CD8 T cell compartments in a short period of time.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Fine analysis of lymphocyte subpopulations in SARS-CoV-2 infected patients: toward a differential profiling of patients with severe outcome 94%
- Long-term T cell perturbations and waning antibody levels in individuals needing hospitalization for COVID-19 94%
- Upregulation of Activation Induced Cell Markers (AIM) among Severe COVID-19 patients in Bangladesh 94%
Similar papers in this journal
Similar papers in this journal
- FINCA disease mouse model exhibits altered behaviour and immune response 92%
- Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration 91%
- Morphological and biochemical repercussions of Toxoplasma gondii infection in a 3D human brain neurospheres model 90%
Similar papers in this journal
- SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy 92%
- Neuroimmune characterization of optineurin insufficiency mouse model during ageing 92%
- Comprehensive Bulk and Single-Cell RNA Sequencing Uncovers Senescence-Associated Biomarkers in Therapeutic Mesenchymal Stem Cells 92%
Similar papers in this journal
- An “In-House” ELISA for SARS-CoV-2 RBD uncovers elevated immune response at higher altitudes 92%
- SARS-CoV-2 viremia precedes an IL6 response in severe COVID-19 patients: results of a longitudinal prospective cohort 92%
- SARS-CoV-2 infection in fully vaccinated individuals of old age strongly boosters the humoral immune response 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.