Exploration of the gut microbiome in Thai patients with major depressive disorder shows a specific bacterial profile with depletion of the Ruminococcus genus as a putative biomarker.

2022-11-10 psychiatry and clinical psychology Title + abstract only

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Maes et al. (2008) published the first paper demonstrating that major depressive disorder (MDD) is accompanied by abnormalities in the microbiota-gut-brain axis, as evidenced by elevated serum IgM/IgA to lipopolysaccharides (LPS) of Gram-negative bacteria, such as Morganella morganii and Klebsiella Pneumoniae. The latter aberrations, which point to increased gut permeability (leaky gut), are linked to activated neuro-immune and oxidative pathways in MDD. To delineate the profile and composition ...

Exploration of the gut microbiome in Thai patients with major depressive disorder shows a specific bacterial profile with depletion of the Ruminococcus genus as a putative biomarker.

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