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Rehabilitation in Survivors of COVID-19 (RE2SCUE): a non-randomized, controlled and open study

Campos, M. C.; Nery, T.; Speck, A. E.; Arpini, M.; Antunes, M. M.; Alves, A. C. d. B.; Santos, N. d. S.; Matos, M. P. P.; Junior, N. S.; Bicca, L. R.; Panisson, C. M.; Freitas, M. A.; Diefenthaeler, F.; Kuriki, H. U.; Damin, V.; da Rosa, R. O.; Gress, J. B.; Schneider, I. J. C.; Vieira, D. S. R.; Arcencio, L.; Aguiar, A.

2022-10-10 rehabilitation medicine and physical therapy
10.1101/2022.10.10.22280907 medRxiv
Show abstract

The sequelae of coronavirus disease-2019 (COVID-19) are another socio-economic problem of the pandemic. Fatigue and dyspnea are the most prevalent symptoms. It is not known whether exercise can be used to treat long COVID-19. This study aimed to investigate the effects of an 8-week face-to-face rehabilitation program on COVID-19 compared to a remote monitoring group. A total of 37 participants (24.3% hospitalized) were assessed before and after rehabilitation (n=22; 40.8{+/-}10.0 years) or remote monitoring (n=15; 45.4{+/-}10.5 years). The participants were allocated according to their preferences. Both groups showed improved fatigue and exercise capacity (Incremental Shuttle Walk Test). Participants in the face-to-face rehabilitation group showed improved dyspnea (Pulmonary Functional Status and Dyspnea Questionnaire), anxiety (Hospital Anxiety and Depression Scale), attention, and short-term memory (d2-R and Reys Auditory-Verbal Learning Test). Of the main sequelae, fatigue improves naturally, whereas dyspnea requires rehabilitation. Our results demonstrated the benefits of exercise for COVID-19 sequelae.

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