Initial niche condition determines the aging speed and regenerative activity of quiescent cells
Liu, Q.; Sheng, N.; Zhang, Z.; He, C.; Zhao, Y.; Sun, H.; Chen, J.; Yang, X.; Tang, C.
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Quiescent cell ages with decline in both the survivability and regenerative activity. While most cellular quiescence/ageing research have focused on the survivability and from the population level, the question how the regenerative activity change with the quiescence time (i.e., chronological age) has rarely been addressed quantitatively. In this work, we systematically measured both features in ageing quiescent fission yeast cells at single cell level. We found that the regenerative activity declines linearly before survivability decline and the cellular chronological ageing speed is predetermined by the initial niche condition. Moreover, this linear ageing behavior is robust under various niche conditions and follows a common ageing trajectory in terms of gene expression. Furthermore, initial calorie restriction was found to improve not only the survivability but also the later regenerative activity. Our results reveal a continuous diverse spectrum of quiescence depth and ageing plasticity.
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