Neurosecretory protein GL-induced fat accumulation is accompanied by repressing the immune-inflammatory response in the adipose tissue of mice
Fukumura, K.; Narimatsu, Y.; Iwakoshi-Ukena, E.; Furumitsu, M.; Bono, H.; Ukena, K.
Show abstract
We have recently identified neurosecretory protein GL (NPGL), a small secretory protein expressed in the vertebrate hypothalamus, as an orexigenic factor with remarkable fat accumulation by overexpression of the NPGL precursor gene (Npgl) for two months. In the present study, we analyzed the effects of short-term Npgl overexpression for 18 days as the early stage of obesity to address the mechanisms underlying obese-like phenotype. Similar to previous studies, short-term Npgl overexpression stimulated food intake and fat accumulation in the white adipose tissues (WAT), whereas the masses of the brown adipose tissue, testis, liver, heart, and muscle remained unchanged. In addition, we observed increased blood insulin and leptin levels due to Npgl overexpression, while little changes were induced in blood glucose, free fatty acids, triglyceride, and cholesterol levels. Furthermore, transcriptome analysis of the inguinal WAT using RNA-sequencing technique revealed that overexpression of Npgl upregulated the genes involved in cytoskeleton regulation, whereas it decreased those involved in immune-inflammatory responses. These results suggest that NPGL plays a crucial role in enlarging adipocytes and suppressing inflammation to avoid metabolic abnormalities, eventually contributing to accelerating energy storage.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide 95%
- G-Protein Coupled Receptor 19 (Gpr19) Knockout Mice Display Sex-Dependent Metabolic Dysfunction 95%
- SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic beta-cells 94%
Similar papers in this journal
- TXN, a Xanthohumol Derivative, Attenuates High-Fat Diet Induced Hepatic Steatosis by Antagonizing PPARγ 96%
- CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction 96%
- Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic disorders 95%
Similar papers in this journal
- Muscle-derived miR-200a-3p through light-intensity exercise may contribute to improve memory dysfunction in type 2 diabetic mice 95%
- NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response 95%
- Cancer causes dysfunctional insulin signaling and glucose transport in a muscle-type specific manner 94%
Similar papers in this journal
Similar papers in this journal
- 17α-estradiol Alleviates High-Fat Diet-Induced Inflammatory and Metabolic Dysfunction in Skeletal Muscle of Male and Female Mice 95%
- Exercise-Induced Benefits On Glucose Handling In A Model Of Diet-Induced Obesity Are Reduced By Concurrent Nicotinamide Mononucleotide 95%
- Differences in metabolic and liver pathobiology induced by two dietary mouse models of nonalcoholic fatty liver disease 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.