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Early detection of SARS-CoV-2 in circulating immune cells in a mouse model

Geng, T.; Keilich, S.; Tafas, F.; WANG, P.

2021-06-30 microbiology
10.1101/2021.06.30.450531 bioRxiv
Show abstract

SARS-CoV-2 infects the respiratory tract, lung and then other organs. However, its pathogenesis remains largely unknown. We used RareScope Fluorescence Light Sheet Microscopy (FLSM) and fluorescent in situ hybridization of RNA (RNA-FISH) to detect SARS-CoV-2 RNA and dissemination kinetics in mouse blood circulation. By RNA-FISH, we found that SARS-CoV-2 RNA-positive leukocytes, including CD11c cells, appeared as early as one day after infection and continued through day 10 post infection. Our data suggest that SARS-CoV-2-permissive leukocytes contribute to systemic viral dissemination, and RNA-FISH combined with FLSM can be utilized as a sensitive tool for SARS-CoV-2 detection in blood specimens.

Matching journals

The top 7 journals account for 50% of the predicted probability mass.

1
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Top 0.2%
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10
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13
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14
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Top 0.1%
1.4%
16
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Top 9%
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Top 2%
1.1%
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Top 3%
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19
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Top 0.5%
1.1%
20
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Top 0.6%
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Top 7%
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Top 3%
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23
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Top 8%
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24
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28
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.