Elucidating the genome of Emydura subglobosa through manual annotation and computational biology tools
Yu, M. R.
Show abstract
Rapid advancements in automated genomic technologies have uncovered many unique findings about the turtle genome and its associated features including olfactory gene expansions and duplications of toll-like receptors. However, automated technologies often result in a high frequency of errors through the process of assembly and annotation and highlight the need for manual annotation. In this study, we have manually annotated four genes of the red-bellied short-neck turtle (Emydura subglobosa), an understudied outgroup of turtles representing a diverse lineage. We improved upon initial ab initio gene predictions through homology-based evidence and generated refined consensus models. Through functional, localization, and structural analyses of the predicted proteins, we have discovered conserved genes encoding proteins that play a role in C21-steroid hormone biosynthetic processes, Vitamin A uptake, collagen/elastin integrity, tumor suppression, and fatty acid catabolism. Overall, these findings further our knowledge about the genetic features underlying turtle physiology, morphology, and longevity, which could have important implications for the treatment of human diseases and evolutionary studies.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Comparison of insect and human cytochrome b561 proteins: Insights into candidate ferric reductases in insects 95%
- Identification and classification of innexin gene transcripts in the central nervous system of the terrestrial slug Limax valentianus 95%
- Unexpected predicted length variation for the coding sequence of the sleep related gene, BHLHE41 in gorilla amidst strong purifying selection across mammals 95%
Similar papers in this journal
- Gene co-expression networks identify novel candidate genes for moulting and development in the Atlantic salmon louse (Lepeophtheirus salmonis) 94%
- Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches 94%
- The Molecular Mass and Isoelectric Point of Plant Proteomes 93%
Similar papers in this journal
Similar papers in this journal
- Comparative analysis of corrected tiger genome provides clues to their neuronal evolution 94%
- The genome of Mekong tiger perch (Datnioides undecimradiatus) provides insights into the phylogenic position of Lobotiformes and biological conservation 94%
- Analysis of human mitochondrial genome co-occurrence networks of Asian population at varying altitudes 94%
Similar papers in this journal
- A Mathematical Genomics Perspective on the Moonlighting Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) 96%
- The Distal-Proximal Relationships Among the Human Moonlighting Proteins: Evolutionary hotspots and Darwinian checkpoints 95%
- Proximal relationships of moonlighting Proteins in Escherichia coli: a mathematical genomic perspective 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.