Cell entry inhibitor with sulfonated colloid gold as new potent broad-spectrum virucides
Chin, C.
Show abstract
We recently developed nontoxic, broad-spectrum virucidal gold nanoparticles, less than 10nm sized, modified with sulfonic acids (mesilate) that mimic heparan sulfates.Camostat, a serine protease inhibitor can introduce gold nanoparticles to the influenza virus via ionic bonds.In this study, we examined the ability of a novel sulfonated colloid gold to inhibit the virus in vivo. Thus, camostat-colloid gold is a promising candidate for the development of antiviral drugs to prevent and treat influenza infection.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Pan-antiviral effects of a PIKfyve inhibitor on respiratory virus infection in human nasal epithelium and mice 95%
- Enisamium reduces influenza virus shedding and improves patient recovery by inhibiting viral RNA polymerase activity 95%
- A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses 92%
Similar papers in this journal
- mRNA Vaccines Encoding Influenza Virus Hemagglutinin (HA) Elicits Immunity in Mice from Influenza A Virus Challenge 93%
- Evaluation of silver nanoparticles for the prevention of SARS-CoV-2 infection in health workers: in vitro and in vivo 93%
- Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo 93%
Similar papers in this journal
- RG203KR mutations in SARS-CoV-2 Nucleocapsid: Assessing the impact using Virus-like particle model system 93%
- Inhibition of BET family proteins suppresses African swine fever virus infection 92%
- TMPRSS2 and RNA-dependent RNA polymerase are effective targets of therapeutic intervention for treatment of COVID-19 caused by SARS-CoV-2 variants (B.1.1.7 and B.1.351) 92%
Similar papers in this journal
- A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseases 93%
- Engineering a mouse-adapted SADS-CoV and establishing a neonatal mouse model to study its infection 92%
- Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model 92%
Similar papers in this journal
- ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection 94%
- Doxycycline inhibition of a pseudotyped virus transduction does not translate to inhibition of SARS-CoV-2 infectivity 93%
- The combination of GS-441524 (remdesivir) and ribavirin results in a potent antiviral effect against human parainfluenza virus 3 infection in human airway epithelial cell cultures and in a mouse infection model 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.