Morphological and Functional Assessment of Thyroid in Individuals with Down Syndrome
Kalil Mangabeira, C. N.; Kalil Mangabeira, R.; Oliveira Andrade, L. J. d.
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Individuals with Downs syndrome (DS) present increased risk for thyroid dysfunction, especially hypothyroidism, due in increased expression of the DYRK1A gene. ObjectiveThe aim of this study was to make a morphological-functional thyroid assessment in individuals with DS. Materials and MethodsThis is a descriptive cross-sectional study, consisting of 29 individuals with DS, with a mean age of 12,3 {+/-} 9,5 (0.66 - 36.00) years, 16 women (55.2%) and 13 men (44.8%), with a morphological-functional thyroid assessment being made comprising hormonal dose (Free T4, TSH), antithyroid antibody (TPOAb and TgAb) and ultrasonography of the thyroid. ResultsTwenty-three (79.3%) individuals presented normal thyroid function while 6 (20.7%) presented with thyroid dysfunction, 4 with hypothyroidism and 2 with hyperthyroidism. Autoimmune thyroiditis and goiter were present in 27.6% of the individuals. ConclusionThyroid function should be assessed periodically in individuals with DS, in view of the high prevalence of thyroid dysfunction, especially autoimmune thyroiditis with consequent hypothyroidism.
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