Plasma exosomal miRNA analysis of Alzheimer's disease reveals the dysfunction of a neural network
Yuzhe, S.; Zhen, H.; Wang, L.; Li, B.; Song, Z.; Deng, Y.; Liu, Z.; Ding, J.; Li, T.; Zhang, W.; Nie, C.; Rong, S.
Show abstract
Exosomal microRNA (miRNA) is an emerging source for biomarkers of Alzheimers disease (AD). Here, we profiled miRNA expression in AD, mild cognitive impairment (MCI), and controls. The assessment and validation of differentially expressed miRNA represented their potential to be novel biomarkers for AD and MCI. We conducted 13 co-expression networks and a miRNA network module linked to neural function emerged as the most significantly associated with AD diagnosis. The conservation analysis revealed the M1 was highly preserved in controls but dysfunction in AD and MCI. The module pattern between MCI and NC was similar, but significantly differed from AD, suggesting that the neural network regulated by miRNA changed during the mild cognitive stage, and the total miRNA expression altered in AD stage. Additionally, 24 out of 26 M1 hub-miRNAs were derived from brain tissue, and 15 had been reported as AD biomarkers. We consequently proposed the other 11 miRNAs could play important roles in AD. Our study highlights that co-expression network analysis can provide a new path for finding novel biomarkers.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Loss of Adaptive DNA Breaks in Alzheimer's Disease Brains 95%
- Common molecular signatures between coronavirus infection and Alzheimer's disease reveal targets for drug development 95%
- Targeted Serum Metabolomic Profiling and Machine Learning Approach in Alzheimer’s Disease using the Alzheimer’s Disease Diagnostics Clinical Study (ADDIA) Cohort 95%
Similar papers in this journal
- Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer's disease model 94%
- Development of an Accelerated Cellular Model for Alzheimer's Disease 94%
- Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites 94%
Similar papers in this journal
- Polygenic effects on the risk of Alzheimer’s disease in the Japanese population 95%
- Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer’s disease 95%
- Interactive Effects of Telomere Length and Genetic Variants on Alzheimer Disease Risk Across Multiple Ancestral Populations 95%
Similar papers in this journal
- Identifying Alzheimer's disease-related pathways based on whole-genome sequencing data 96%
- Artificial intelligence-driven meta-analysis of brain gene expression data identifies novel gene candidates in Alzheimer’s Disease 96%
- Scale Bar of Aging Trajectories for Screening Personal Rejuvenation Treatments 90%
Similar papers in this journal
- Mitochondrial small RNA alterations associated with increased lysosome activity in an Alzheimer's Disease Mouse Model uncovered by PANDORA-seq 97%
- IPSC-derived neuronal cultures expressing the Alzheimer’s disease associated rare TREM2 R47H variant enables the construction of an Aβ-induced gene regulatory network 95%
- Different RNA profiles in plasma derived small and large extracellular vesicles of Neurodegenerative diseases patients. 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.