The shifting of dominating roles between structural cells and immune cells are key regulators of human adipose tissues aging
Zhou, W.; Lin, J.; Hu, X.; Yao, X.; Hongwei, O.
Show abstract
Adipose tissue is a highly dynamic organ with complex cellular composition. Aging induces adipose tissue function decline and relocation of peripheral adipose tissue to abdominal compartment, which often associated with inflammation and metabolic disorders. Here we performed single-cell RNA sequencing to comprehensively and unbiasedly deconvolve how subcutaneous adipose tissue (SAT) responses to aging. We collected >25,000 stromal vascular cells from abdominal and gluteofemoral SAT of young and old donors. Analyses of transcription signatures and cell networks uncovered impaired adipogenesis and extracellular matrix synthesis capacity of APC, altered metabolic phenotype of immune cells and shifted tissue-dominating cells that can be used to predict adipose tissue aging. We also reported aging-associated distinct transcriptional program between gluteofemoral SAT and abdominal SAT. Our work thus reveals unanticipated cellular, immunological, metabolic and site-specific aspects of human adipose tissues aging process, providing valuable resource for better understanding of aging-associated adipose tissue dysfunction.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Single-cell RNA sequencing identifies accumulation of Fcgr2b+ virtual memory like CD8 T cells with cytotoxic and inflammatory potential in aged mouse white adipose tissue 96%
- LEF1 isoforms regulate cellular senescence and aging 96%
- A single short reprogramming early in life improves fitness and increase lifespan in old age 95%
Similar papers in this journal
- Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging 95%
- GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging 95%
- Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation 95%
Similar papers in this journal
Similar papers in this journal
- Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging 96%
- Aged mouse ovarian immune milieu shows a shift towards adaptive immunity and attenuated cell function 95%
- Metformin alleviates aging-associated cellular senescence of human adipose stem cells and derived adipocytes 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.