Aglycone polyether ionophores as broad-spectrum agents inhibit multiple enveloped viruses including SARS-CoV-2 in vitro and successfully cure JEV infected mice
Liu, T.; Li, J.-Q.; Huang, M.; Zhang, Y.-N.; Liu, R.; Zhang, Z.-R.; Zhang, Q.-Y.; Wang, Y.; Liu, J.; Deng, Z.; Zhang, B.; Ye, H.-Q.
Show abstract
Infections with zoonotic viruses, such as flaviviruses, influenza virus, and the SARS-CoV-2 pandemic coronavirus constitute an increasing global risk. Hence, an urgent need exists for the development of broad-spectrum antivirals to prevent such outbreaks. Here, we show that the maduramycin and CP-80,219 aglycone polyether ionophores exhibit effective broad-spectrum antiviral activity, against various viruses, including Japanese encephalitis virus (JEV), Dengue virus (DENV), Zika virus (ZIKV), and Chikungunya virus (CHIKV), while also exhibiting promising activity against PR8 influenza virus and SARS-CoV-2. Moreover, liposome-encapsulated maduramycin and CP-80,219 provide full protection for mice from infection with JEV in vivo. Mechanistic studies suggest that aglycone polyether ionophores primarily inhibit the viral replication step without blocking endosome acidification to promote the fusion between viral and cellular membranes. The successful application of liposomes containing aglycone polyether ionophores in JEV-infected mice offers hope to the development of broad-spectrum antiviral drugs like penicillin back to 1940s.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses in cell culture 96%
- The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators 94%
- Drug repurposing screening identified tropifexor as a SARS-CoV-2 papain-like protease inhibitor 93%
Similar papers in this journal
- Antiviral activity of lambda-carrageenan against influenza viruses in mice and severe acute respiratory syndrome coronavirus 2 in vitro 97%
- The Effect Of Famotidine On SARS-CoV-2 Proteases And Virus Replication 95%
- HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2 94%
Similar papers in this journal
- Atazanavir inhibits SARS-CoV-2 replication and pro-inflammatory cytokine production 97%
- A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses 96%
- Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs 95%
Similar papers in this journal
- Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity 95%
- Discovery of benzophenanthridine derivatives with potent activity against multidrug resistant Mycobacterium tuberculosis 93%
- Inhibition of BET family proteins suppresses African swine fever virus infection 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.