Identification of specific biomarkers and pathways in the synovial tissues of patients with osteoarthritis in comparison to rheumatoid arthritis
Gu, H.; Yuan, G.
Show abstract
Osteoarthritis and rheumatoid arthritis are two common arthritis with different pathogenesis. Here, we explore the difference of genes and biological pathways in human synovial fibroblasts by using a bioinformatics method to clarify their potential pathogenesis. The GSE7669 dataset was originally produced by using an Affymetrix Human Genome U95 platform. We used the KEGG and GO analysis to identify the functional categories and pathways. Our results suggested that biological adhesion and cell adhesion are the main signaling pathways in osteoarthritis in comparison to rheumatoid arthritis. Furthermore, Albumin, MAPK3, PTPRC, COL1A1, and CXCL12 may be key genes in osteoarthritis. Therefore, our study provides potential targets for the specific and accurate therapy of osteoarthritis.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Beneficial influence of single-stage posterior surgery for the treatment of lumbar brucella spondylitis combined with spondylolisthesis 94%
- Multi-tissue network analysis for drug prioritization in knee osteoarthritis 93%
- Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice 93%
Similar papers in this journal
- RORβ modulates a gene program that is protective against articular cartilage damage 94%
- The role of BMP6 in the proliferation and differentiation of chicken cartilage cells 94%
- Investigation of locomotive syndrome improvement by total hip arthroplasty in patients with hip osteoarthritis: a before-after comparative study focusing on 25-question geriatric locomotive function scale 94%
Similar papers in this journal
- Mast cells differentiated in synovial fluid and resident in osteophytes exalt the inflammatory pathology of osteoarthritis 96%
- From miRNA target gene network to miRNA function: miR-375 might regulate apoptosis and actin dynamics in the heart muscle via Rho-GTPases-dependent pathways 93%
- Transcriptomic changes during the replicative senescence of human articular chondrocytes 92%
Similar papers in this journal
- A small H2O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase 92%
- A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions 92%
- Analysis of serum trace elements, macro-minerals, antioxidants, malondialdehyde and immunoglobulins in seborrheic dermatitis patients: A case-control investigation 91%
Similar papers in this journal
- Paired transcriptomic analyses of atheromatous and control vessels reveal novel autophagy and immunoregulatory genes in peripheral artery disease 92%
- Human Sex Matters: Y-linked lysine demethylase 5D drives accelerated male osteogenic differentiation 90%
- Stem cell factor and granulocyte colony-stimulating factor promote remyelination in the chronic phase of severe traumatic brain injury 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.