Back

A Novel Class of Azoles with potent Anti-Leishmanial activity

Mathur, T.; Kumar, M.; Barman, T. K.; Raj, S. V.; Upadhyay, D. J.; Verma, A. K.

2020-10-16 microbiology
10.1101/2020.10.16.342329 bioRxiv
Show abstract

ObjectivesTo investigate the anti-leishmanial activity of novel azole compounds against Leishmania donovani, which causes deadly visceral leishmaniasis disease. MethodsA focused azole-based library was screened both against promastigotes and amastigotes forms of L. donovani strains in flat-bottomed 96-well tissue-culture plates and J774A.1 macrophages infected with L. donovani. The comprehensive screening azole-based library against L. donovani strains provided novel hits, which can serve as a good starting point to initiate hit to lead optimization campaign. ResultsHits identified from azole-based library exhibited potent in vitro activity against promastigotes and amastigotes of L. donovani. ConclusionsThese potent novel azole hits could be a good starting point to carry out for further medicinal chemistry exploration for anti-leishmania program.

Matching journals

The top 4 journals account for 50% of the predicted probability mass.

1
PLOS Neglected Tropical Diseases
● 466 papers in training set
Top 0.5%
19.8%
Similar papers in this journal
2
PLOS ONE
● 5266 papers in training set
Top 11%
16.1%
Similar papers in this journal
3
Antimicrobial Agents and Chemotherapy
● 187 papers in training set
Top 0.2%
13.8%
Similar papers in this journal
4
Parasites & Vectors
○ 60 papers in training set
Top 0.3%
7.2%
Similar papers in this journal
50% of probability mass above
5
Scientific Reports
○ 3612 papers in training set
Top 27%
3.7%
Similar papers in this journal
6
ACS Infectious Diseases
● 82 papers in training set
Top 0.4%
3.4%
7
Microbiology Spectrum
● 469 papers in training set
Top 5%
2.6%
8
Frontiers in Cellular and Infection Microbiology
○ 109 papers in training set
Top 1%
1.8%
9
Microorganisms
○ 106 papers in training set
Top 1%
1.8%
10
Malaria Journal
○ 58 papers in training set
Top 0.6%
1.2%
11
Frontiers in Pharmacology
○ 111 papers in training set
Top 2%
1.2%
12
The American Journal of Tropical Medicine and Hygiene
● 68 papers in training set
Top 1%
1.1%
13
Infection, Genetics and Evolution
○ 42 papers in training set
Top 0.6%
1.1%
14
International Journal for Parasitology
○ 26 papers in training set
Top 0.5%
1.1%
15
ACS Omega
● 105 papers in training set
Top 3%
1.1%
16
Molecules
○ 39 papers in training set
Top 1%
0.7%
17
eLife
● 5828 papers in training set
Top 68%
0.7%
18
Heliyon
○ 152 papers in training set
Top 8%
0.7%
19
Pathogens
○ 56 papers in training set
Top 2%
0.7%
20
Transactions of The Royal Society of Tropical Medicine and Hygiene
◐ 18 papers in training set
Top 0.6%
0.7%
21
Frontiers in Microbiology
○ 427 papers in training set
Top 8%
0.7%
22
Frontiers in Immunology
○ 638 papers in training set
Top 10%
0.7%
23
Vaccines
○ 198 papers in training set
Top 4%
0.5%
24
Acta Tropica
○ 13 papers in training set
Top 0.7%
0.5%
25
International Journal of Molecular Sciences
○ 494 papers in training set
Top 18%
0.5%
26
Journal of Microbiological Methods
○ 13 papers in training set
Top 0.6%
0.5%
27
Antibiotics
○ 34 papers in training set
Top 1%
0.5%
28
International Journal of Antimicrobial Agents
○ 15 papers in training set
Top 0.6%
0.5%
29
mSphere
● 302 papers in training set
Top 8%
0.5%
30
Journal of Global Antimicrobial Resistance
○ 17 papers in training set
Top 0.7%
0.5%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.