Mutation in position of 32 (G>U) of S2M differentiate human SARS-CoV2 from Bat Coronavirus
Vahed, M.; Vahed, M.; Sweeney, A.; Shirazi, F. H.; Mirsaeidi, M.
Show abstract
The new Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a zoonotic pathogen that has rapidly mutated and become transmissible to humans. There is little existing data on the mutations in SARS-CoV-2 and the impact of these polymorphisms on its transmission and viral load. In this study, the SARS-CoV-2 genomic sequence was analyzed to identify variants within the 3UTR region of its cis-regulatory RNA elements. A 43-nucleotide genetic element with a highly conserved stem-loop II-like motif (S2M), was discovered. The research revealed 32 G>U and 16 G>U/A mutations located within the S2M sequence in human SARS-CoV-2 models. These polymorphisms appear to make the S2M secondary and tertiary structures in human SARS-CoV-2 models less stable when compared to the S2M structures of bat/pangolin models. This grants the RNA structures more flexibility, which could be one of its escape mechanisms from host defenses or facilitate its entry into host proteins and enzymes. While this S2M sequence may not be omnipresent across all human SARS-CoV-2 models, when present, its sequence is always highly conserved. It may be used as a potential target for the development of vaccines and therapeutic agents.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mutational spectra of SARS-CoV-2 orf1ab polyprotein and Signature mutations in the United States of America 96%
- Effects of SARS-CoV-2 Mutations on Protein Structures and Intraviral Protein-Protein Interactions 95%
- Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS-CoV-2 variants 95%
Similar papers in this journal
- SARS-CoV-2: Proof of recombination between strains and emergence of possibly more virulent ones 97%
- Analysis the molecular similarity of least common amino acid sites in ACE2 receptor to predict the potential susceptible species for SARS-CoV-2 95%
- Structural impact of synonymous mutations in six SARS-CoV-2 Variants of Concern 95%
Similar papers in this journal
- Prediction and Evolution of B Cell Epitopes of Surface Protein in SARS-CoV-2 94%
- HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors 93%
- Characterization of accessory genes in coronavirus genomes 93%
Similar papers in this journal
- Comparison of Oxidative and Hypoxic Stress Responsive Genes from Meta-Analysis of Public Transcriptomes 91%
- Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells 91%
- Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.