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Adopting STING agonist cyclic dinucleotides as a potential adjuvant for SARS-CoV-2 vaccine
Wu, J.-J.; Chen, Y.-X.; Li, Y.-M.
2020-07-24
immunology
10.1101/2020.07.24.217570
bioRxiv
Show abstract
A novel STING agonist CDGSF unilaterally modified with phosphorothioate and fluorine was synthesized. CDGSF displayed better STING activity over dithio CDG. Immunization of SARS-CoV-2 Spike protein with CDGSF as an adjuvant elicited an exceptional high antibody titer and a robust T cell response, which were better than the group using aluminium hydroxide as a adjuvant. These results highlighted the adjuvant potential of STING agonist in SARS-CoV-2 vaccine preparation for the first time.
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