ARG1 could be expressed by human, but not represent for repair
Chu, C.; Hu, C.; Rong, S.; Wang, Y.; Qu, Y.; Man, Y.
Show abstract
Arginase 1 (ARG1), typically expressed under stress or stimulation rather than in the healthy condition in humans. However, more and more studies claim ARG1 could be expressed by human and represents healing process. Including THP-1 monocyte shift to M2 macrophages rendered a higher expression of ARG1 than that with bone-graft has an ideal effect on anti-inflammation, resulting in tissue healing. With the higher expression of ARG1 seemingly induced by the constructed material and represented by the anti-inflammatory situation. For these reasons, this study focuses on whether traditional markers of macrophages could be express by human or not during clinical healing process. Through harvesting bone tissue samples during bone healing process and confirm the expression of markers at transcriptome and protein levels. The results showed the expression of ARG1 relatively low by bulk-RNA sequencing, quantitative polymerase chain reaction (qPCR), immunofluorescence (IF) and flow cytometry or could not be detected during process of healing of healthy donor. Taken together, results indicate that the ARG1 is not chosen for a regenerative marker in human bone tissue.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Human Platelet Lysate as Alternative of Fetal Bovine Serum for Enhanced Human in vitro Bone Resorption and Remodeling 93%
- Dose-dependent phorbol 12-myristate-13-acetate-1 mediated monocyte-to-macrophage differentiation induces unique proteomic signatures in THP-1 cells 92%
- Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation. 92%
Similar papers in this journal
- C-Jun N-terminal kinase (JNK) pathway activation is essential for dental papilla cells polarization 95%
- TGF-β expressed by M2 macrophages promotes wound healing by inhibiting TSG-6 expression by mesenchymal stem cells 94%
- Mesenchymal Stem/ Stromal Cells metabolomic and bioactive factors profiles: a comparative analysis on the Umbilical Cord and Dental Pulp derived Stem/ Stromal Cells secretome 94%
Similar papers in this journal
- MicroRNA-155 regulates osteogenesis and bone mass phenotype via targeting S1PR1 gene 97%
- Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice 95%
- Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling 95%
Similar papers in this journal
- RT-qPCR analyses on the osteogenic differentiation from human iPS cells: An investigation of reference genes 95%
- Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice 95%
- Image matters: Development of a novel staining method, the RGB-trichrome, as a reliable tool for the study of the musculoskeletal system 94%
Similar papers in this journal
- Mast cells differentiated in synovial fluid and resident in osteophytes exalt the inflammatory pathology of osteoarthritis 95%
- Interferon-gamma and TNF-alpha synergistically enhance the immunomodulatory capacity of Endometrial-Derived Mesenchymal Stromal Cell secretomes by differential microRNA and extracellular vesicle release 94%
- Hematopoietic growth factors Regulate Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.