Lifestyle Changes In Patients With Non-Alcoholic Fatty Liver Disease: A Systematic Review Protocol
Fernandez, T. R.; Vinuela, M.; Barrera, F.; Arab, J. P.; Arrese, M.; Cabrera, D.
Show abstract
Non-alcoholic fatty liver disease (NAFLD) is a worldwide raising liver condition and it is expected to become the first cause of progression to cirrhosis and hepatocellular carcinoma in the next 5 years (Araujo 2018). At present, there are no pharmacological treatments approved. Weight loss is the first-line treatment (European Association for the Study of the Liver 2016) (Chalasani 2012) showing that 7 to 10% weight loss improves steatosis, inflammation, hepatocyte ballooning and, in NASH patients, has an impact in fibrosis too (Romero-Gomez 2017). However, the reduction and maintenance of weight loss is often complex. To achieve this goal, it is recommended doing lifestyle changes including exercise and diet on daily living (Hannah 2016). However, it has been difficult to establish any conclusions regarding the best type of diet or exercise protocol to maximize improvements and to maintain its effects through time. Because of this, the objective of this review is assessing the efficacy and safety of diet, exercise, or a combination of these in patients with NAFLD.
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