Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate
Arora, K.; Rastogi, R.; Arora, N. M.; Parashar, D.; Paliwal, J.; Naqvi, A.; Srivastava, A.; Singh, S. K.; Kalyanaraman, S.; Potdar, S.; Kumar, D.; Arya, V. B.; Bansal, S.; Rautray, S.; Singh, I.; Fengade, P. S.; Kumar, B.; Kundu, P. K.
Show abstract
Spike, Envelope and Membrane proteins from the SARS CoV-2 virus surface coat are important vaccine targets. We hereby report recombinant co-expression of the three proteins (Spike, Envelope and Membrane) in a engineered Saccharomyces cerevisiae platform (D-Crypt) and their self-assembly as Virus-like particle (VLP). This design as a multi-antigenic VLP for SARS CoV-2 has the potential to be a scalable vaccine candidate. The VLP is confirmed by transmission electron microscopy (TEM) images of the SARS CoV-2, along with supportive HPLC, Dynamic Light Scattering (DLS) and allied analytical data. The images clearly outline the presence of a "Corona" like morphology, and uniform size distribution.
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