Gut microbiota impairs insulin clearance during obesity
Foley, K. P.; Zlitni, S.; Duggan, B. M.; Barra, N.; Anhe, F. F.; Cavallari, J. F.; Henriksbo, B. D.; Chen, C. Y.; Huang, M.; Lau, T.; Schertzer, J. D.
Show abstract
Hyperinsulinemia can be a cause and consequence of obesity and insulin resistance. Increased insulin secretion and reduced insulin clearance can contribute to hyperinsulinemia. The triggers for changes in insulin clearance during obesity are ill-defined. We found that oral antibiotics mitigated impaired insulin clearance in mice fed a high fat diet (HFD) for 12 weeks or longer. Short-term HFD feeding and aging did not alter insulin clearance in mice. Germ-free mice colonized with microbes from HFD-fed mice had impaired insulin clearance, but not C-peptide clearance, and only after mice were colonized for 6 weeks and then HFD-fed. Five bacterial taxa predicted >90% of the variance in insulin clearance. Our data indicate that gut microbes are an independent and transmissible factor that regulates obesity-induced changes in insulin clearance. A small cluster of microbes may be a target for mitigating defects in insulin clearance and the progression of obesity and Type 2 Diabetes. We propose that a small community in the gut microbiota can impair insulin clearance and increase insulin load and the risk of complications from hyperinsulinemia.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium 95%
- Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processes 95%
- Gut Microbiota and Derived Metabolites Mediate Obstructive Sleep Apnea Induced Atherosclerosis 95%
Similar papers in this journal
- Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice 97%
- Short-term consumption of ultra-processed semi-synthetic diets impairs the sense of smell and brain metabolism in mice 95%
- Dietary isoleucine content defines the metabolic and molecular response to a Western diet 94%
Similar papers in this journal
- Metabolic endotoxemia is dictated by the type of lipopolysaccharide 96%
- Atypical gut microbial ecosystem from athletes with very high exercise capacity improves insulin sensitivity and muscle glycogen store in mice 95%
- Brown adipose expansion and remission of glycemic dysfunction in obese SM/J mice 94%
Similar papers in this journal
- Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition 95%
- Dietary modulation alters susceptibility to Listeria monocytogenes and Salmonella typhimurium in a gut microbiota-independent manner 95%
- Physical activity shapes the intestinal microbiome and immunity of healthy mice but has no protective effects against colitis in MUC2-/- mice 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.