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Urine proteome changes in an α-synuclein transgenic mouse model of Parkinson's disease

Li, L.; Pan, X.; Wang, T.; Hua, Y.; Gao, Y.

2020-04-05 biochemistry
10.1101/2020.04.05.026104 bioRxiv
Show abstract

Urine accommodates more changes than other fluids, and it is a good source in the search for early sensitive biomarkers. The present study collected urine samples from 2-, 4-, 6-, 8- and 10-month-old -synuclein transgenic mice. Based on data-independent acquisition (DIA) technology, liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used for quantitative analysis. Seventeen human homologous differential proteins were screened and compared with those in the urine of 2-month-old mice, and 9 proteins were related to Parkinsons disease (PD). Formin-2, Splicing factor 3A subunit 1, and Isopentenyl-diphosphate Delta-isomerase 1 changed continuously in months 6, 8 and 10. These experiments and analyses demonstrated that the urine proteome reflected the development of -synuclein transgenic mice and provided clues for the early clinical diagnosis of PD.

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